Drugs to Pass the Blood Brain Barrier
DISCLAIMER: I am not a qualified physician and none of the below should be read as medical advice. I am merely sharing my research.
With the recent discovery (Feb. 2019) of a new brain metastasis, I have been reassessing my supplement and repurposed drug protocol to ensure I am maximising the blood brain penetration. This is a work in progress but below I share some preliminary thoughts and links to research in case it can help someone else:
Milk thistle made by this brand Legalon has shown particular success in inhibiting the growth of brain mets in lung and other cancer patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924887/
The recommended dose may be 5 pills a day.
The type used in the study contains Vit E, which can be controversial for cancer patients, but the manufacturer make another without:
Below are the types not containing Vitamin E
Apons.eu
https://www.apons.eu/legalon-forte-madaus-hartkapseln-180-st?ecs_campaign=ide
When ordering, be careful that you order article Nr. 11548215 "Legalon Forte Madaus“ made by MEDA Pharma GmbH .
Mebendezole - trialled at John Hopkins for recurrent brain tumours where the dose is 500mg/day
https://clinicaltrials.gov/ct2/show/NCT02644291?term=Mebendazole&rank=1
Melatonin crosses the blood brain barrier:
https://www.ncbi.nlm.nih.gov/pmc/articles/
https://www.mdpi.com/1422-0067/18/4/843
20mg dose recommended and available on iherb
Boswellia - to reduce edema (brain swelling caused by brian mets) as a natural alternative to dexamethason: https://www.ncbi.nlm.nih.gov/m/pubmed/21287538/?fbclid=IwAR1Rhxd28QevG4D3zdCpQUyZVCyGqhu176Dw_yGLBcYIpTIquo2dxgtbUv0
Or if you want a larger dose, the largest I can find is 2000mg on Amazon:
Febendezole based on anecdotal stories of remission including one patient with brain mets who believes FBZ helped these alone.
https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective
Why to combine FBZ with vitamins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/
Must take with this form of vitamin E: https://www.amazon.com/Life-Extension-Tocopherols-Tocotrienols-Softgels/dp/B000VHV3BM
Mifeprestone: https://www.ncbi.nlm.nih.gov/pubmed/24778047
To read : https://lung_cancer.quandora.com/m#/q/c46af380-4e7d-4b72-a9af-a80750b9c907
Research on repurposed drugs to cross the blood brain barrier:
