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    Drugs to Pass the Blood Brain Barrier

     

    DISCLAIMER: I am not a qualified physician and none of the below should be read as medical advice. I am merely sharing my research.

     

    With the recent discovery (Feb. 2019) of a new brain metastasis, I have been reassessing my supplement and repurposed drug protocol to ensure I am maximising the blood brain penetration. This is a work in progress but below I share some preliminary thoughts and links to research in case it can help someone else:

     

    Milk thistle made by this brand Legalon has shown particular success in inhibiting the growth of brain mets in lung and other cancer patients.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924887/

    The recommended dose may be 5 pills a day.

    The type used in the study contains Vit E, which can be controversial for cancer patients, but the manufacturer make another without: 

     

    Below are the types not containing Vitamin E

     

    Apons.eu  

    https://www.apons.eu/legalon-forte-madaus-hartkapseln-180-st?ecs_campaign=ide

     

    https://disapo.de

    https://disapo.de/bin/geossql.pl?Sid=disapo-10916423134-1551018759&Stype=Pzn&Scont=11548215&Kc=00&Gban=

     

    When ordering, be careful that you order article Nr. 11548215  "Legalon Forte Madaus“  made by MEDA Pharma GmbH .

     

    Mebendezole - trialled at John Hopkins for recurrent brain tumours where the dose is 500mg/day 

    https://clinicaltrials.gov/ct2/show/NCT02644291?term=Mebendazole&rank=1

     

    Melatonin crosses the blood brain barrier:
    https://www.ncbi.nlm.nih.gov/pmc/articles/
    https://www.mdpi.com/1422-0067/18/4/843
    20mg dose recommended and available on iherb

     

    Boswellia - to reduce edema (brain swelling caused by brian mets) as a natural alternative to dexamethason: https://www.ncbi.nlm.nih.gov/m/pubmed/21287538/?fbclid=IwAR1Rhxd28QevG4D3zdCpQUyZVCyGqhu176Dw_yGLBcYIpTIquo2dxgtbUv0

    Available on iherb

    Or if you want a larger dose, the largest I can find is 2000mg on Amazon:


    Febendezole based on anecdotal stories of remission including one patient with brain mets who believes FBZ helped these alone.
    https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective

     

    Why to combine FBZ with vitamins

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

     

    Must take with this form of vitamin E: https://www.amazon.com/Life-Extension-Tocopherols-Tocotrienols-Softgels/dp/B000VHV3BM

     

    Mifeprestone: https://www.ncbi.nlm.nih.gov/pubmed/24778047

     

    To read : https://lung_cancer.quandora.com/m#/q/c46af380-4e7d-4b72-a9af-a80750b9c907

     

    Research on repurposed drugs to cross the blood brain barrier: 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833171/?fbclid=IwAR22ny18siRY4bjy5nMUtBOxYU1fA7rMOR4R7G3z_pG-fqS5bOQgjOiY6KQ